Duloxetine Versus Placebo in the Treatment of Patients with Osteoarthritis Knee Pain

This research study was designed to find out if duloxetine is safe and effective in treating adults who have been diagnosed with OA knee pain. Duloxetine is a medication that has been used to treat fibromyalgia, depression and pain associated with peripheral diabetic neuropathy. There is evidence to suggest that it may be an effective way of helping to reduce OA knee pain. This international study examined the effectiveness and safety of duloxetine for treating OA pain among men and women aged 40 years or older.

Participants in the study were people who had been experiencing such pain for at least 14 days of each month for the past 3 months, who were able to walk without crutches or a walker, and had not been diagnosed with depression. They attended 6 study visits over approximately 16 weeks, took up to three capsules a day of the study medication or placebo, and completed a daily pain diary during the 13-week treatment period.

Recruitment and subsequent data collection for this project ended in the fall of 2007.

Investigator

Gillian Hawker (PI), Jacqueline Hochman (MSc candidate)

Staff

Samra Mian, Melissa French

Date

2007+
Last modified: June 13, 2008